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Doctor of Philosophy [Ph.D] [PhD in Pharmacy and Pharmaceutical Sciences, Investigating the biomolecular interactions between innate blood defense systems] From Cardiff University

Cardiff, WalesLocation

UniversitySchool type

Estd1883established year

24245enrollment

Public

8.1/10

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Doctor of Philosophy [Ph.D] (PhD in Pharmacy and Pharmaceutical Sciences, Investigating the biomolecular interactions between innate blood defense systems)

3 years

Full Time

Field of Study:

University allocates places on a first-come, first-served basis, so students are recommended to apply as early as possible.

Complement and coagulation are both blood-based proteolytic cascades and integral defence mechanisms that typically protect against pathogen invasion and bleeding.
Although they have distinct functions, complement and coagulation share many structural motifs, are evolutionary linked and several points of cross-talk between each pathway has been recently identified.
However, the mechanisms by which these systems co-operate to maintain health and their role in disease pathogenesis, when dysregulated, is still incompletely understood.
Our group have recently characterised one aspect of this cross-talk, which occurs between thrombomodulin and factor H. We found that the anticoagulant thrombomodulin has moderate complement regulatory activity that is both factor H-dependent and independent (Heurich et al 2016).

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