How difficult is it for a fresher to be in the top 10 at TAPMI? Do you have any advice towards the same?

Yes, it is possible for a fresher with hard work and diligence.

It has nothing to do with the fact that you are a new student or work-ex. As long as you know what you want it's not because you're a fresher or work-ex. You can improve, develop, and utilize your skills if you know what you want from yourself. You'll get more than expected. My advice is to study hard, find subjects you like (you might think you like one but end up loving another), follow your hobbies (it's a busy program, but your interests don't have to die), enjoy the place (Manipal is a beautiful city inside and out, and you might never get the chance to go back), and make a lot of friends because networking is important.