Trust me there are no issues at all for a North Indian to study at KMC Manipal. Almost 60–70 % of students are North Indians. Almost everyone you have to interact with knows Hindi. However, you might face issues with clinical postings because most patients have only a basic understanding of Hindi. You will have to learn basic Kannada for which classes are taken in college in the second year.
The food is not a big issue at all because breakfast is South Indian comprising dishes like mini dosas, idlis, vadas. Bread, butter, and jam are served daily. Students are given rajma rice, Chole Bhature, and paneer once a week each. The roti served is very good and you will get Dal and rice daily.
Additionally, there are many that sell delicious food around the campus. There is also a mall within a 10-minute walking distance so you can visit Pizza Hut, Domino's, and CCD anytime.